Halting the Epidemic of Addiction and Loss Act of 2025

This bill requires the Health and Human Services (HHS) Secretary to update all HHS grant program regulations and guidance related to opioid misuse to include *all* FDA-approved opioid overdose reversal drugs - not just naloxone. It specifically targets two key grant programs: the State Opioid Response Grants (under the 21st Century Cures Act) and the Tribal Opioid Response Grants, plus the Public Health Service Act's grant program for regional/national substance use disorder prevention. HHS must update existing references within one year of the bill's enactment to ensure grants cover any approved reversal drug. This directly affects states, tribes, and community organizations receiving these federal grants for opioid response programs.