To amend the Foreign Assistance Act of 1961 to modify treatment activities for assistance to combat HIV/AIDS.

HR 4627 amends the Foreign Assistance Act of 1961 to update U.S. foreign aid programs combating HIV/AIDS. It specifically adds funding for HIV pre-exposure prophylaxis (PrEP) medications as a covered activity and designates all HIV prevention efforts - including those targeting at-risk populations identified by the World Health Organization - as "core life-saving humanitarian assistance." This change ensures such prevention activities receive priority funding under U.S. foreign aid programs. The bill directly affects how U.S. government agencies allocate resources for global HIV/AIDS prevention initiatives.