To amend the Endangered Species Act of 1973 to expand the exemption process under section 7 of that Act with respect to national security and significant adverse national or regional economic impacts.

HR 3845 amends the Endangered Species Act to expand when federal agencies or project applicants can seek exemptions from species protection requirements. It allows exemptions if a project might harm endangered species but would either impair national security or cause significant adverse national/regional economic impacts. The bill adds new criteria requiring consultation with the National Security Council and National Economic Council before finalizing such exemptions. This change directly affects federal agencies, state governors, and project applicants seeking to bypass ESA protections for certain projects.