Protecting Life and Integrity in Research Act of 2025

This bill prohibits federal funding, support, or approval for research using human fetal tissue obtained from induced abortions. It allows research on tissue from miscarriages (under 20 weeks) or stillbirths (20+ weeks) under existing Public Health Service Act rules, and permits development of new cell lines for vaccines or genetic vectors if not derived from abortion tissue. The bill amends the Public Health Service Act to restrict federal research to tissue from miscarriages or stillbirths and clarifies definitions for terms like "miscarriage" and "stillbirth." It directly affects federal agencies like the NIH and researchers relying on federal grants for biomedical studies.