HEARTS Act of 2025

This bill creates a new National Center for Alternatives to Animals in Research and Testing within the National Institutes of Health (NIH). It requires NIH to establish incentives for researchers to adopt non-animal methods - such as organoids, AI models, and 3D human cell systems - before approving animal-based studies, and mandates that all federally funded institutions publicly report annual animal usage data by species. Covered entities must also submit biennial plans to reduce animal use and update their reports every two years. The law aims to implement a 1993 congressional mandate for reducing animal research through transparency, new resources, and standardized evaluation of alternatives.