To direct the Secretary of Health and Human Services to establish an Office of Rural Health, and for other purposes.

HR 5481 directs the Secretary of Health and Human Services to create a new Office of Rural Health within the Centers for Disease Control and Prevention (CDC). The office will coordinate CDC research, develop policies (including telehealth solutions), and award grants to address rural health challenges like access to care and health disparities. This bill directly affects rural populations by focusing federal efforts on improving their health outcomes through coordinated CDC initiatives.