Holidays and Days of Special Observance - As enacted, designates October 1 of each year as "APDS Day" to promote awareness of activated PI3K delta syndrome. - Amends TCA Title 15, Chapter 2.

SB 2130 designates October 1 of each year as "APDS Day" in Tennessee to raise awareness of activated PI3K delta syndrome (APDS), a rare genetic immune disorder affecting approximately 1-2 people per million. The bill directly impacts Tennesseans diagnosed with APDS, who often face delayed diagnoses (averaging seven years), frequent infections, developmental challenges, and higher cancer risks. It establishes an annual observance to increase public and medical recognition of the condition, encouraging earlier diagnosis and family testing. The law takes effect upon enactment and does not include funding or treatment mandates.