Modifies provisions relating to the administration of controlled substances by nurses

HB 1981 modifies Missouri law to allow certain nurses to prescribe controlled substances under specific conditions. It permits advanced practice registered nurses (APRNs) with a special certificate to prescribe Schedule III-V drugs and limited Schedule II drugs (only hydrocodone for hospice patients), with a 120-hour supply limit and a ban on self-prescribing. Certified nurse anesthetists (CRNAs) can administer controlled substances during anesthesia care without needing a prescriptive certificate. The bill requires written agreements between physicians and nurses to delegate prescribing authority and updates rules for handling unused medications.