HB 1643 Missouri House · 2026 Regular Session

Modifies provisions relating to alternative therapies and treatments, including psilocybin

HB 1643 legalizes limited personal use of psilocybin (a compound found in "magic mushrooms") for therapeutic purposes under strict conditions. It directly affects adults aged 21+ with qualifying conditions like end-of-life care, PTSD, major depression, or substance use disorders, as documented by a physician. Key provisions require users to obtain medical documentation, use a trained facilitator (with specific qualifications), undergo lab testing, and limit intake to 150mg annually. The bill also shields facilitators, healthcare providers, and labs from legal penalties for compliant use, while maintaining patient confidentiality.
Bill status in committee 1 of 4 stages cleared
Introduction
Dec 2025
Committee Review
Floor Vote
Governor
Introduced Dec 1, 2025 Last action Feb 26, 2026
Floor votes

How they voted

No floor votes recorded yet.
Full legislative history

Actions timeline

Total actions
8
Key actions
2
Committee
3
Feb 26, 2026
Lower · Passed
HCS Reported Do Pass (H) - AYES: 7 NOES: 2 PRESENT: 2
lower
Feb 25, 2026
Lower · Passed
HCS Voted Do Pass (H)
lower
Feb 12, 2026
Committee
Referred: Emerging Issues(H)
lower
Dec 1, 2025
Introduced
Prefiled (H)
lower
1 primary · 0 co-sponsors

Sponsors

Role
Legislator
Party
State
District
P
Photo of Matthew Overcast
Matthew Overcast
RRepublican
MO
155